There are three games featuring a matchup of Top 25 teams on Saturday, with the headliner being No. 11 Utah playing at No. 18 UCLA (3:30 p.m. ET on FOX) in a battle of 2-0 teams in Pac-12 Conference play.
Raise your hand if you expected TCU and Kansas to be ranked in the Top 25 in Week 6? The No. 17 Horned Frogs (1-0 Big 12, 4-0 overall) play at the No. 19 Jayhawks (2-0, 5-0) at 12:30 p.m. ET on FS1.
The other pairing of ranked teams is No. 8 Tennessee (1-0, 4-0) playing at No. 25 LSU (2-0, 4-1) in an Southeastern Conference interdivision showdown.
Another noteworthy game among independents is Notre Dame playing No. 16 BYU in the Shamrock Series in Las Vegas.
Here’s everything you need to know about the Top 25 college football odds for Week 6 — the point spread, moneyline and total over/under (with all college football odds via FOX Bet).
All times ET
SATURDAY’S GAMES
No. 4 Michigan @ Indiana (12 p.m., FOX)
Point spread: Michigan -22.5 (Michigan favored to win by more than 22.5 points, otherwise Indiana covers)
Moneyline: Michigan -1429 favorites to win (bet $10 to win $10.70 total); Indiana +700 underdogs to win (bet $10 to win $80 total)
Total scoring over/under: 59 points scored by both teams combined
No. 8 Tennessee @ No. 25 LSU (12 p.m., ESPN)
Point spread: Tennessee -3 (Tennessee favored to win by more than 3 points, otherwise LSU covers)
Moneyline: Tennessee -149 favorites to win (bet $10 to win $16.71 total); LSU +115 underdogs to win (bet $10 to win $21.50 total)
Total scoring over/under: 65 points scored by both teams combined
No. 17 TCU @ No. 19 Kansas (12 p.m., FS1)
Point spread: TCU -6.5 (TCU favored to win by more than 6.5 points, otherwise Kansas covers)
Moneyline: TCU -250 favorites to win (bet $10 to win $14 total); Kansas +190 underdogs to win (bet $10 to win $29 total)
Total scoring over/under: 68.5 points scored by both teams combined
Arkansas @ No. 23 Mississippi State (12 p.m., SEC Network)
Point spread: Mississippi State -9.5 (Mississippi State favored to win by more than 9.5 points, otherwise Arkansas covers)
Moneyline: Mississippi State -345 favorites to win (bet $10 to win $12.90 total); Arkansas +260 underdogs to win (bet $10 to win $36 total)
Total scoring over/under: 59.5 points scored by both teams combined
South Florida @ No. 24 Cincinnati (2:30 p.m., ESPN+)
Point spread: Cincinnati -27.5 (Cincinnati favored to win by more than 27.5 points, otherwise South Florida covers)
Moneyline: Cincinnati -10000 favorites to win (bet $10 to win $10.10 total); South Florida +1400 underdogs to win (bet $10 to win $150 total)
Total scoring over/under: 59.5 points scored by both teams combined
Auburn @ No. 2 Georgia (3:30 p.m., CBS)
Point spread: Georgia -30 (Georgia favored to win by more than 30 points, otherwise Auburn covers)
Moneyline: Georgia -10000 favorites to win (bet $10 to win $10.10 total); Auburn +1600 underdogs to win (bet $10 to win $26 total)
Total scoring over/under: 49 points scored by both teams combined
Texas Tech @ No. 7 Oklahoma State (3:30 p.m., FS1)
Point spread: Oklahoma State -9.5 (Oklahoma State favored to win by more than 9.5 points, otherwise Texas Tech covers)
Moneyline: Oklahoma State -333 favorites to win (bet $10 to win $13 total); Texas Tech +240 underdogs to win (bet $10 to win $34 total)
Total scoring over/under: 69.5 points scored by both teams combined
No. 11 Utah @ No. 18 UCLA (3:30 p.m., FOX)
Point spread: Utah -3.5 (Utah favored to win by more than 3.5 points, otherwise UCLA covers)
Moneyline: Utah -175 favorites to win (bet $10 to win $15.71 total); UCLA +135 underdogs to win (bet $10 to win $23.50 total)
Total scoring over/under: 64.5 points scored by both teams combined
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No. 3 Ohio State @ Michigan State (4 p.m., ABC)
Point spread: Ohio State -27 (Ohio State favored to win by more than 27 points, otherwise Michigan State covers)
Moneyline: Ohio State -10000 favorites to win (bet $10 to win $10.10 total); Michigan State +1600 underdogs to win (bet $10 to win $170 total)
Total scoring over/under: 65 points scored by both teams combined
No. 9 Ole Miss @ Vanderbilt (4 p.m., SEC Network)
Point spread: Ole Miss -17 (Ole Miss favored to win by more than 17 points, otherwise Vanderbilt covers)
Moneyline: Ole Miss -769 favorites to win (bet $10 to win $11.30 total); Vanderbilt +500 underdogs to win (bet $10 to win $60 total)
Total scoring over/under: 62 points scored by both teams combined
No. 21 Washington @ Arizona State (4 p.m., Pac-12 Network)
Point spread: Washington -14 (Washington favored to win by more than 14 points, otherwise Arizona State covers)
Moneyline: Washington -667 favorites to win (bet $10 to win $11.50 total); Arizona State +400 underdogs to win (bet $10 to win $50 total)
Total scoring over/under: 57.5 points scored by both teams combined
No. 5 Clemson @ Boston College (7:30 p.m., ABC)
Point spread: Clemson -20.5 (Clemson favored to win by more than 20.5 points, otherwise Boston College covers)
Moneyline: Clemson -1429 favorites to win (bet $10 to win $10.70 total); Boston College +700 underdogs to win (bet $10 to win $80 total)
Total scoring over/under: 48.5 points scored by both teams combined
Washington State @ No. 6 USC (7:30 p.m., FOX)
Point spread: USC -13 (USC favored to win by more than 13 points, otherwise Washington State covers)
Moneyline: USC -500 favorites to win (bet $10 to win $12 total); Washington State +300 underdogs to win (bet $10 to win $40 total)
Total scoring over/under: 66 points scored by both teams combined
South Carolina @ No. 13 Kentucky (7:30 p.m., SEC Network)
Point spread: Kentucky -9.5 (Kentucky favored to win by more than 9.5 points, otherwise South Carolina covers)
Moneyline: Kentucky -400 favorites to win (bet $10 to win $12.50 total); South Carolina +280 underdogs to win (bet $10 to win $38 total)
Total scoring over/under: 49.5 points scored by both teams combined
Army @ No. 15 Wake Forest (7:30 p.m., ESPN3)
Point spread: Wake Forest -17 (Wake Forest favored to win by more than 17 points, otherwise Army covers)
Moneyline: Wake Forest -714 favorites to win (bet $10 to win $11.43 total); Army +450 underdogs to win (bet $10 to win $55 total)
Total scoring over/under: 66.5 points scored by both teams combined
No. 16 BYU vs. Notre Dame @ Las Vegas (7:30 p.m., NBC/Peacock)
Point spread: Notre Dame -3.5 (Notre Dame favored to win by more than 3.5 points, otherwise BYU covers)
Moneyline: Notre Dame -182 favorites to win (bet $10 to win $15.49 total); BYU +140 underdogs to win (bet $10 to win $24 total)
Total scoring over/under: 51 points scored by both teams combined
No. 20 Kansas State @ Iowa State (7:30 p.m., ESPNU)
Point spread: Kansas State -2 (Kansas State favored to win by more than 2 points, otherwise Iowa State covers)
Moneyline: Kansas State -133 favorites to win (bet $10 to win $17.52 total); Iowa State +105 underdogs to win (bet $10 to win $20.50 total)
Total scoring over/under: 45 points scored by both teams combined
Texas A&M @ No. 1 Alabama (8 p.m., CBS)
Point spread: Alabama -24 (Alabama favored to win by more than 24 points, otherwise Texas A&M covers)
Moneyline: Alabama -2500 favorites to win (bet $10 to win $10.40 total); Texas A&M +900 underdogs to win (bet $10 to win $100 total)
Total scoring over/under: 51 points scored by both teams combined
No. 12 Oregon @ Arizona (8 p.m., TV TBA)
Point spread: Oregon -13.5 (Oregon favored to win by more than 13.5 points, otherwise Arizona covers)
Moneyline: Oregon -500 favorites to win (bet $10 to win $12 total); Arizona +300 underdogs to win (bet $10 to win $40 total)
Total scoring over/under: 70 points scored by both teams combined
Florida State @ No. 14 North Carolina State (8 p.m., ACC Network)
Point spread: North Carolina State -3 (North Carolina State to win by more than 3 points, otherwise Florida State covers)
Moneyline: North Carolina State -167 favorites to win (bet $10 to win $15.99 total); Florida State +130 underdogs to win (bet $10 to win $23 total)
Total scoring over/under: 51 points scored by both teams combined
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