Top Serie A Matches Betting Analysis & Odds for Matchday 1

Expect plenty of great Serie A soccer action this weekend. Starting on Saturday, August 21, teams like Inter Milano, Juventus, and AC Milan step onto the pitch hoping to add a win to their record. Keep reading for Serie A odds, analysis, and free picks for this weekend’s top Serie A matches.  

Top UEFA Serie A Games to Watch This Weekend (Aug 21st – Aug 23rd)

Sassuolo +155 vs Hellas Verona +160

  • When: Saturday, Aug. 21

Hellas Verona won their Coppa Italia match on Aug. 14 and this takes place on their field. The road team, though, has won the last couple of head-to-head. Sassuolo looks like the best play. 

Soccer Pick: Sassuolo  

Genoa +1 ½ (-125) vs Inter Milano -1 ½ (-105)

  • When: Saturday, Aug. 21

This is defending champion Inter Milano’s first match of the season. Genoa played in a Coppa Italia match on Aug. 13. Who knows if Inter will be as good this Serie A season as they were last season. One thing is certain, though, as long as Lautaro Martinez plays for them, Inter should handle teams like Genoa on the handicap.  

Soccer Pick: Inter Milano  

Atalanta -1 ½ (+133) vs Torino +1 ½ (-178)

  • When: Saturday, Aug. 21

Atalanta has lost 3 straight, including dropping a club friendly 1-3 to Juventus in their last. These two drew 3-3 on Feb. 6. In the match before, Atalanta beat Torino 4-2. The road squad is worth a look. 

Soccer Pick: Atalanta 

Lazio -131 vs Empoli +320

  • When: Saturday, Aug. 21

Empoli makes the jump from Serie B to Serie A. Lazio is one of the better teams in Serie A. So Empoli has their work cut out for them. But the upstart plays Lazio at home while the road squad heads into this having lost 3-of-5 with a single win and a draw. Empoli gets the nod. 

Soccer Pick: Empoli  

Salernitana +350 vs Bologna -142

  • When: Sunday, Aug. 22

The odds make Bologna an underlay. Yes, Bologna played in Serie A last season while Salernitana played in Serie B. But the road squad has won 4-of-5. At +350, Salernitana is the play. 

Soccer Pick: Salernitana  

Juventus -1 ½ (+133) vs Udinese +1 ½ (-178)

  • When: Sunday, Aug. 22

Juventus should be much better this season than they were last season. So even though Udinese takes on Ronaldo and his mates on their pitch, the home squad should be up against it. The odds don’t justify a bet on Udinese while Juvy has a big shot to win this by at least 2.

Soccer Pick: Juventus 

Fiorentina +310 vs AS Roma -135

  • When: Sunday, Aug. 22

Going back to 2019, Roma has won the last 4 head-to-head matches. Fiorentina beat Cosenza 4-0 in a Coppa Italia contest on Aug. 13. We must assume that after last season, AS plays with more fire this season. The home team wins.   

Soccer Pick: AS Roma  

Venezia +1 ½ (+107) vs Napoli -1 ½ (-142) 

  • When: Sunday, Aug. 22

Last season, Venezia played well in Serie B. This season, they should struggle. Napoli is such a huge favorite that they’re at -142 on the handicap giving up a goal and a half. It would be nice if we could back Venezia getting 1 ½ goals at above even money. But Napoli has won 4-of-5 with a draw. The home team beat Bayern Munich 3-0 in their last match, a club friendly on July 31. 

Soccer Pick: Napoli  

Spezia +245 vs Cagliari +101

  • When: Monday, Aug. 23

Both teams won their first Coppa Italia match. Cagliari has an edge because this takes place on their grass. Spezia won the last head-to-head. If the odds gap wasn’t so significant, we might back Cagliari. At +245, though, Spezia is the play. 

Soccer Pick: Spezia  

AC Milan -117 vs Sampdoria +295

  • When: Monday, Aug. 23

How much has AC Milan improved? That’s the big question. Heading into this match, Sampdoria shows much better form. Maybe, Milan beats the home squad. But the odds don’t justify a bet on AC. The odds on Sampdoria makes the home team an overlay. 

Soccer Pick: Sampdoria


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